REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics
The REBUS model explains psychedelic effects as a relaxation of the brain's high-level priors, letting bottom-up signals write more freely — a complete, mainstream neuroscientific account in which vivid "other realities" are generated entirely inside the skull, with no external world required. It is deliberately included as the honest counterweight: if this record asks whether the perceived reality is real, the strongest naturalistic "no" belongs on the shelf beside the "maybe." DOI 10.1124/pr.118.017160.
- Authors
- Robin L. Carhart-Harris, Karl J. Friston
- Journal
- Pharmacological Reviews
- Published
- 2019-07-01
- DOI
- 10.1124/pr.118.017160
- Content type
- Paper
- Authority
- Academic
- Stance score
- -6
Abstract
The REBUS model explains psychedelic effects as a relaxation of the brain's high-level priors, letting bottom-up signals write more freely — a complete, mainstream neuroscientific account in which vivid "other realities" are generated entirely inside the skull, with no external world required. It is deliberately included as the honest counterweight: if this record asks whether the perceived reality is real, the strongest naturalistic "no" belongs on the shelf beside the "maybe." DOI 10.1124/pr.118.017160.
Topics
- Academic Paper
- Critique
- Neurobiology
- Predictive Processing
- psilocybin
- LSD
- DMT
Citation
Robin L. Carhart-Harris, Karl J. Friston (2019) REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics. Pharmacological Reviews. doi:10.1124/pr.118.017160
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