A Pilot Mechanistic RCT of Psilocybin With Mindfulness-based Therapy vs Support for Posttraumatic Stress Disorder (PTSD)
The goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD). This is an assessor-blinded, randomized, controlled study in participants with PTSD. The study will investigate the changes in brain activity, connectivity, and microstructural neuroplasticity assessed using EEG/EMG and multimodal MRI measures after administration of one oral dose of psilocybin, accompanied either with standard "psychological support" only; or with standard support plus Mindfulness-based Cognitive Therapy (MBCT).
- Status
- recruiting
- Phase
- Phase 2
- Institution
- Anthony P King
- Start date
- 2026-07-01
- End date
- 2029-12-01
- Registry ID
- NCT07104916
Tracked by the DMT Code Clinical Trials Observatory, an open record of DMT-related clinical research.