Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults
Participants in this study will undergo a series of non-invasive tests and activities designed to understand how a single dose of psilocybin might influence cognition and emotional well-being in healthy older adults. After providing written informed consent, eligible participants, aged between 60 and 85, will be randomly assigned to receive a dose of psilocybin ranging from a microdose to a moderate-to-high dose. Anatomical magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) will be used to assess changes in brain structure, while functional magnetic resonance imaging (fMRI) will be used to quantify changes in functional brain activity.
- Status
- recruiting
- Phase
- Phase 1
- Institution
- University of California, Berkeley
- Start date
- 2025-11-01
- End date
- 2027-12-30
- Registry ID
- NCT06367738
Tracked by the DMT Code Clinical Trials Observatory, an open record of DMT-related clinical research.