An Investigation of Strategies to Understand and Optimize the Antidepressant Effects of Psilocybin (The OPTIMIZE Study)
This study will examine the effects of a single dose of psilocybin, administered with psychological support, on symptoms of depression. It will also assess whether different post-dosing interventions, including a non-invasive technique called transcutaneous auricular Vagus Nerve Stimulation (taVNS), influence various psychological and behavioral outcomes. In addition, the study will explore objective measures of real-world social behavior and identify early behavioral responses that may be associated with long-term treatment outcomes.
- Status
- recruiting
- Phase
- Phase 2
- Institution
- Charles Raison
- Principal investigator
- Charles Raison, MD
- Start date
- 2025-05-13
- End date
- 2029-05-01
- Registry ID
- NCT06512194
Tracked by the DMT Code Clinical Trials Observatory, an open record of DMT-related clinical research.