Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication in Patients With Chronic Pain: an Open-label Feasibility Study
This is an open-label pilot trial to assess the safety and feasibility of a novel 8-week psilocybin-assisted psychotherapy intervention to facilitate successful tapering/discontinuation of opioid pain medication in adult patients receiving long-term opioid therapy for chronic pain. Participation will last approximately 8 months and includes one or two psilocybin-assisted therapy sessions. The study will evaluate the incidence and severity of adverse events during and after treatment, the number of participants who drop out of the study for intervention-related reasons, and the self-reported benefits and harms of the intervention.
- Status
- recruiting
- Phase
- Phase 2
- Institution
- University of British Columbia
- Principal investigator
- W. Francois Louw, MD
- Start date
- 2025-10-27
- End date
- 2026-08-31
- Registry ID
- NCT05585229
Tracked by the DMT Code Clinical Trials Observatory, an open record of DMT-related clinical research.