Dexmedetomidine-esketamine-ropivacaine Versus Sufentanil-ropivacaine Combination for Epidural Labor Analgesia and Neonatal Outcomes: a Pilot Randomized Trial
Sufentanil-ropivacaine combination is commonly used for epidural labor anesthesia, but is associated with some adverse events. Dexmedetomidine and esketamine, each has been effectively used for neuraxial anesthesia in combination with local anesthetics. Plenty of evidences show that both dexmedetomidine and esketamine, combined with ropivacaine, are also effective as the sufentanil-ropivacaine combination when used for epidural labor analgesia. This pilot trial is designed to evaluate the efficacy and safety of the dexmedetomidine-esketamine-ropivacaine versus sufentanil-ropivacaine combination for epidural labor analgesia, and to test the feasibility of a future large randomized trial.
- Status
- completed
- Phase
- Phase 4
- Institution
- Peking University First Hospital
- Principal investigator
- Dong-Xin Wang, MD,PhD
- Start date
- 2025-09-05
- End date
- 2026-03-13
- Registry ID
- NCT07145775
Tracked by the DMT Code Clinical Trials Observatory, an open record of DMT-related clinical research.