Psilocybin and Affective Function in Chronic Lower Back Pain Depression
This study seeks to provide insight on psilocybin's effects on mechanisms of chronic pain among patients with co-morbid chronic low back pain and depression (CLBP+D). Participants will receive either a single high-dose of psilocybin (25mg absolute dose) or methylphenidate (40mg absolute dose). Participants will be asked to complete assessments of pain, depressive symptoms, and more general questionnaires regarding the participants experiences during the experimental sessions and the associated enduring effects.
- Status
- recruiting
- Phase
- Phase 1
- Institution
- Johns Hopkins University
- Principal investigator
- David B Yaden, PhD
- Start date
- 2024-04-22
- End date
- 2026-12-30
- Registry ID
- NCT06355414
Tracked by the DMT Code Clinical Trials Observatory, an open record of DMT-related clinical research.